C(sp[3])-H Bond Functionalization of 8-Methylquinolines.
Chem Asian J. 2025 Mar 03; 20(5):e202401266.CA

Abstract

Quinolines have emerged as essential components in various medicinal agents, playing a key role in treating various ailments. Numerous drugs with a quinoline core have been recognized for their antimalarial, antibacterial, and anticancer activities and have been successfully commercialized, including chloroquine, ciprofloxacin, topotecan, etc. Over the past two decades, a tremendous expansion in the C-H bond functionalization of quinoline scaffolds to widen this chemical space for drug discovery have been witnessed. This review article summarizes the efforts toward C(sp[3])-H functionalization of 8-methylquinolines for C(sp[3])-C/X bond formation under metal and metal-free strategies. Each section briefly overviews the C(sp[3])-H functionalization of 8-methylquinoline, highlighting the metal and metal-free approaches.

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Authors+Show Affiliations

Parmar D

C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur, HP 176061, India.

Kumar R

C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur, HP 176061, India. Current Address: Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.

Sharma U

C-H Activation & Phytochemistry Lab, Chemical Technology Division, CSIR-IHBT, Palampur, HP 176061, India.

Pub Type(s)

Journal Article

Review

Language

eng

PubMed ID

39736085

Citation

Parmar, Diksha, et al. "C(sp[3])-H Bond Functionalization of 8-Methylquinolines." Chemistry, an Asian Journal, vol. 20, no. 5, 2025, pp. e202401266.

Parmar D, Kumar R, Sharma U. C(sp[3])-H Bond Functionalization of 8-Methylquinolines. Chem Asian J. 2025;20(5):e202401266.

Parmar, D., Kumar, R., & Sharma, U. (2025). C(sp[3])-H Bond Functionalization of 8-Methylquinolines. Chemistry, an Asian Journal, 20(5), e202401266. https://doi.org/10.1002/asia.202401266

Parmar D, Kumar R, Sharma U. C(sp[3])-H Bond Functionalization of 8-Methylquinolines. Chem Asian J. 2025 Mar 3;20(5):e202401266. PubMed PMID: 39736085.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - C(sp[3])-H Bond Functionalization of 8-Methylquinolines. AU - Parmar,Diksha, AU - Kumar,Rohit, AU - Sharma,Upendra, Y1 - 2025/02/06/ PY - 2024/12/21/revised PY - 2024/09/24/received PY - 2024/12/30/medline PY - 2024/12/30/pubmed PY - 2024/12/30/entrez KW - 8-methylquinolines KW - C(sp3)−H functionalization KW - meta-free C−H functionalization KW - transition metal-catalysis SP - e202401266 EP - e202401266 JF - Chemistry, an Asian journal JO - Chem Asian J VL - 20 IS - 5 N2 - Quinolines have emerged as essential components in various medicinal agents, playing a key role in treating various ailments. Numerous drugs with a quinoline core have been recognized for their antimalarial, antibacterial, and anticancer activities and have been successfully commercialized, including chloroquine, ciprofloxacin, topotecan, etc. Over the past two decades, a tremendous expansion in the C-H bond functionalization of quinoline scaffolds to widen this chemical space for drug discovery have been witnessed. This review article summarizes the efforts toward C(sp[3])-H functionalization of 8-methylquinolines for C(sp[3])-C/X bond formation under metal and metal-free strategies. Each section briefly overviews the C(sp[3])-H functionalization of 8-methylquinoline, highlighting the metal and metal-free approaches. SN - 1861-471X UR - https://www.unboundmedicine.com/medline/citation/39736085/C(sp[3])-H_Bond_Functionalization_of_8-Methylquinolines. DB - PRIME DP - Unbound Medicine ER -

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C(sp[3])-H Bond Functionalization of 8-Methylquinolines.Chem Asian J. 2025 Mar 03; 20(5):e202401266.CA